General description
An extremely selective dopamine D2 receptor agonist (Ki = 9 nM). Commonly used in Parkinson′s Disease models and to reproduce cocaine′s discriminative stimulus effects. Sumanirole has greater than 200-fold selectivity for the D2 receptor subtype versus the other dopamine receptor subtypes in radioligand binding assays. In cell-based assays, sumanirole is a fully efficacious agonist, with EC50 values between 17 and 75 nM. In animals, sumanirole elicits many physiological responses attributed to D2-like receptor function.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Achat-Mendes, C. et al., 2010. J. Pharmacol. Exp. Ther.334, 556.McCall, R. B. et al., 2005. J. Pharmacol. Exp. Ther.314, 1248.
Packaging
5 mg in Glass bottle
Warning
Toxicity: Standard Handling (A)
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